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Rosuvastatin calcium dosage should be adjusted in asian patients see dosage and administration and clinical pharmacology .

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Simeprevir, which is a hepatitis c virus hcv protease inhibitor, or combinations of atazanavir ritonavir or lopinavir ritonavir, which are hiv-1 protease inhibitors, increase rosuvastatin exposure auc up to threefold see table 4 clinical pharmacology 12.

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Pharmacokinetic studies have demonstrated an approximate 2-fold increase in median exposure to rosuvastatin in asian subjects when compared with caucasian controls.

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